February 11, 2024

“受肥胖和糖尿病影响最强烈的脑区为下丘脑弓状核”

2:04 PM

“弓状核神经元-室旁核回路”

2:05 PM

“EVs含有脂质、DNA、RNA和蛋白质等生物活性分子，是天然的细胞间信号，因此可作为天然的纳米药物载体。 5 更重要的是，EVs 还具有穿越 BBB 的能力。结合低免疫原性和良好生物相容性的优势，EVs 是一类前景广阔的生物纳米载体，可用于改善神经系统疾病的治疗”

11:09 AM

“我们设计了一种能传递 NSC 招募信号并激活其神经元分化能力的生物工程纳米药物，用于缺血性中风的治疗”

11:09 AM

“（SDF-1）共价接枝到EVs表面，以发出NSC招募信号（SDF-1-EVs”

11:10 AM

“静脉注射后，SDF-1-EVs可穿过BBB并在缺血区域聚集”

11:11 AM

“SDF-1-EVs能有效促进NSC迁移及其神经元分化”

11:14 AM

“虽然EVs可以突破BBB治疗神经系统疾病，但静脉注射EVs仍然容易被单核吞噬细胞系统迅速清除，这对达到治疗药物浓度是一个障碍。”

11:59 AM

“通过将 SDF-1-EVs 加入 MSs 中，构建了 SDF-1-EVs 龛（S-EVs@MS），并将其立体注射到 tMCAO 模型大鼠的脑腔内。”

12:04 PM

“when we are unsure of what is best to do (uncertainty); when the evidence of what is best to do comes from numerous others (the many); and when that evidence comes from people like us (similarity).”

4:34 AM

“One way uncertainty develops is through lack of familiarity with the situation. Under such circumstances, people are especially likely to follow the lead of others.”

4:44 AM

“the failure of bystanders to aid victims in agonizing need of help.”

4:48 AM

“Often an emergency is not obviously an emergency.”

5:30 AM

“Once it is understood that the enemy is the state of uncertainty, it becomes possible for emergency victims to reduce this uncertainty, thereby protecting themselves”

7:43 AM

“As claquing grew and developed, its practitioners offered an array of styles and strengths—the *pleureuse*, chosen for her ability to weep on cue; the *bisseur*, who called “*bis*” (repeat) and “encore” in ecstatic tones; and the *rieur*, selected for the infectious quality of his laugh.”

8:07 AM