February 25, 2024

“In my quest to become the greatest bodybuilder ever, I trained five hours a day for fifteen years. When I got to America, I took my workouts up a level and invented the double split, where I trained two and a half hours in the morning and two and a half hours in the evening, just so I could get two full workouts in each day”

4:51 PM

“When I retired from bodybuilding and transitioned into acting, I took those five daily training hours and allocated them to the work of becoming a leading man”

4:51 PM

“the dosage of gastrodin is always high in clinical use as well as in preclinical models, for gastrodin has been proven to be a non-toxic compound in acute and subacute toxicity experiments, thus a certain amount of gastrodin could enter CNS despite of its poor BBB permeability”

8:34 AM

“Brain ECs maintain the integrity of the blood–brain barrier (BBB) and regulate transport across it, but are also functionally active in controlling processes such as blood clotting and matching blood flow to neural activity (neurovascular coupling). Importantly, they also interact with brain cells on their abluminal side”

4:37 AM

“EC dysfunction has recently been implicated in the mechanism of parenchymal change through cellular interactions and secretions, in addition to the critical role of ECs in neurovascular coupling and BBB function”

4:39 AM

“direct impact of EC dysfunction on white matter (WM) change via cellular interactions”

4:39 AM

“At the blood vessel end of the unit is the blood–brain barrier, consisting of endothelial cells, pericytes, astrocytic end-feet, and the basement membrane”

5:40 AM

“EC dysfunction has been shown to be key in the pathogenesis of SVD, occurring prior to BBB breakdown”

5:41 AM

“Endothelial dysfunction is usually defined in relation to endothelium-derived nitric oxide (NO), which promotes blood vessel dilation, with dysfunctional ECs synthesising and releasing less NO”

5:42 AM

“The terms endothelial dysfunction and vascular dysfunction are often used interchangeably, as NO regulates local vascular responses as well as ECs, but the two are distinct and do not always coexist (e.g., vascular dysfunction can be caused by EC-independent mechanisms rooted in pericytes or smooth muscle cells)”

5:44 AM

“Microvascular function in diabetic mice partially changes around 8–10 weeks after DM onset (C57BL/6 mice”

12:44 AM