February 26, 2024
3 books · 12 highlights · 1 notes
Exosomes, a New Star for Targeted Delivery 外泌体--靶向递送的新星
Frontiers
“As carriers, exosomes hold promise as advanced platforms for targeted drug/gene delivery, owing to their unique properties, such as innate stability, low immunogenicity and excellent tissue/cell penetration capacity.”
12:09 PM
“Various studies have shown that exosomes are prospective vehicles for therapeutic small molecules, such as curcumin, paclitaxel and doxorubicin (DOX).”
12:10 PM
The biology, function, and biomedical applications of exosomes 外泌体的生物学、功能和生物医学应用
Raghu Kalluri
“Exosomes can be engineered to deliver diverse therapeutic payloads, including short interfering RNAs, antisense oligonucleotides, chemotherapeutic agents, and immune modulators, with an ability to direct their delivery to a desired target”
11:57 AM
“外泌体可能会促进或限制大脑中未折叠和异常折叠蛋白质的聚集”
12:02 PM
“Exosomes could participate in the clearing of misfolded proteins, thereby exerting detoxifying and neuroprotective functions, or participate in the propagation and aggregation of misfolded proteins, effectively promoting the “infectivity” of protein aggregates and contributing to disease progression”
12:03 PM
外泌体和TTR的交集
✎ NOTE
“Exosomes may impair neurotoxic oligomer formation ([133](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717626#R133)) or exosomes may carry them out of cells ([134](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717626#R134))”
12:04 PM
“Extracellular vesicles round off communication in the nervous system.”
12:05 PM
“Exosomes in Parkinson’s disease: Current perspectives and future challenges.”
12:06 PM
“The role of extracellular vesicles in neurodegenerative diseases.”
12:06 PM
“Exosomes in the diseased brain: First insights from *in vivo* studies.”
12:06 PM
Influence
Robert B. Cialdini, PhD
“They’ve also located an activity to help prevent the occurrence of this destructive sequence: prayer—not prayer in general, though, but of a particular kind. If one romantic partner agrees to say a brief prayer *for the other’s well-being* every day, he or she becomes less likely to be unfaithful during the period of time while doing so. After all, such behavior would be inconsistent with daily active commitments to the partner’s welfare.”
2:45 AM
““I was wondering if you would tell me exactly why you’ve chosen to purchase your insurance with <our company>.””
2:46 AM